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KMID : 0903520090520040367
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 4 p.367 ~ p.370
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Anti-Helicobacter pylori Diarylheptanoid Identified in the Rhizome of Alpinia officinarum
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Lee Haeng-Byung
Lee Hyun-Kyung
Kim Jun-Ran
Ahn Young-Joon
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Abstract
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The antibacterial activity of materials derived from the rhizome of Alpinia officinarum (Zingiberaceae) against Helicobacter pylori ATCC 43504, ATCC 700392, and ATCC 700824 was examined using paper-disc diffusion and agar dilution methods. Results were compared with those following treatment with currently used antibiotics: amoxicillin, metronidazole, and tetracycline. The bioactive principle was characterized as the diarylheptanoid 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone by spectroscopic analysis. This compound was isolated from A. officinarum leaves as a new anti- H. pylori principle. Against H. pylori ATCC 43504, ATCC 700392, and ATCC 700824, the antibacterial activity of the diarylheptanoid (48, 24, and 24 μg/mL) was comparable to that of metronidazole (32, 16, and 16 μg/mL) but less effective than that of either amoxicillin (0.06, 0.06, and 0.03 μg/mL) or tetracycline (0.5, 1, and 0.5 μg/mL), based on minimum inhibitory concentrations. A. officinarum rhizome-derived materials, particularly the diarylheptanoid isolated, merit further study as potential antibacterial functional food products or therapeutic products for prevention or eradication from humans from diseases caused by H. pylori.
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KEYWORD
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Alpinia officinarum, diarylheptanoid, 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone, Helicobacter pylori, natural antibacterial agent
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